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Biomimetic Cementless Technology
 

BONITRepresenting a new generation in cementless coating technology, Biomimetic Cementless Technology is a bone-like cementless coating with more than 15 years' clinical history(1,2). The microcrystalline structure of the calcium phosphate (CaP) coating maintains substrate surface roughness, providing a large area for bone integration. Its biphasic composition is designed to enhance rapid osseointegration, while the coating morphology provides a potent capillary effect, which may help to accelerate the implant healing process(1,2,3,4,5,6).

Properties

Biomimetic Cementless Technology is produced via a room-temperature electrolytic deposition process that results in the formation of a 15μm thin, needle-like, microcrystalline coating (brushite), similar in morphology to natural bone tissue. This surface structure is designed to facilitate integration into the bone tissue development process(3,4,5,7,8). The needle-like CaP crystals are stacked parallel to each other, creating a hydrophilic effect beneficial for the adsorption of growth factors and adhesion of bone cells(6).

UniglideUnlike conventional '˜line of sight' plasma spraying processes, electrolysis allows for complete and uniform coverage of all exposed implant surfaces, whilst maintaining the surface roughness of the underlying titanium porous coated implant(4).

A biphasic CaP coating, the soluble brushite phase in Biomimetic Cementless Technology gets resorbed rapidly promoting short-term bone synthesis. In vivo studies have shown that, unlike conventional, highly crystalline HA coatings, the co-ordinated bioactivity exhibited by Biomimetic Cementless Technology provides excellent short and long-term osseointegration(1,2,3,5,7,9).

Clinical trials have demonstrated that Biomimetic Cementless Technology is fully resorbable, disappearing into the joint space within 8-12 weeks of implantation, allowing for exposure of the porous structure to rapidly deposited bone tissue(3,10).  This provides instant mechanical interlock between the developing bone and underlying implant.

 


References:

1. Wood PLR, Deakin S. Total ankle replacement. The results in 200 ankles. J Bone Joint Surg (Br) 2003; 85-B:3:334.

2. Saxler G, Temmen D, Bontemps G. Medium-term results of AMC-unicompartmental knee arthroplasty. The Knee 2004; 11:39-355.

3. Schwarz ML, Kowarsch M, Rose SB, Jani L. Histomorphometrical and mechanical evaluation of various surfaces on titanium test bodies placed into femora of the Göttinger minipig. Can a resorbable CaP coating increase osteointegration? 49th Annual Meeting of the Orthopaedic Research Society 2003; Poster.

4. DOT GmbH internal test report. Data on file Corin Group 2009.

5. Becker P, Nebe B, Luthen F, Rychle J, Neumann HG. Cellular investigations on electrochemically deposited CaP-composite. 18th European Conference on Biomaterials 2003. Abstract.

6. Szmukler-Moncler S, Becker P, Kunemann P, Nardin M. Capillarity measurement of various FBR/BONIT-coated titanium surfaces. European Association for Osseointegration 2003; Poster.

7. Zeggel P. Bioactive Calcium phosphate coatings for dental implants. A summarising characterisation of BONIT-FBR. International Magazine of Oral Implantology 1/2000; 51-57.

8. Zeggel P, Becker P. BONIT®. A biomimetic calcium phosphate coating connects bone and implant surfaces. BONEZone Summer 2003.

9. Massei G, Trisi P, Malchiodi L, Szmukler-Moncler S. Immediately loaded FBR-coated PITT-EASY BIO-OSS Implants. A histologic evaluation in 3 patients after 8-12 weeks of function. European Association for Osseointegration 2001; Poster.

10. Becker P, Zeggel P, Luthen F, Nebe B, Rychly J, Neumann HG. Resorbable calcium phosphate composite coatings. Key Engineering Materials 2002; 218-220:653-656.



 


Important: Not all products are available or cleared for distribution in all international markets. For more details, please contact your local subsidiary or distributor by visiting the Corin worldwide section.

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