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Biomimetic Cementless Technology

BONITRepresenting a new generation in cementless coating technology, Biomimetic Cementless Technology is a bone-like cementless coating with more than 15 years' clinical history(1,2). The microcrystalline structure of the calcium phosphate (CaP) coating maintains substrate surface roughness, providing a large area for bone integration. Its biphasic composition is designed to enhance rapid osseointegration, while the coating morphology provides a potent capillary effect, which may help to accelerate the implant healing process(1,2,3,4,5,6).


Biomimetic Cementless Technology is produced via a room-temperature electrolytic deposition process that results in the formation of a 15μm thin, needle-like, microcrystalline coating (brushite), similar in morphology to natural bone tissue. This surface structure is designed to facilitate integration into the bone tissue development process(3,4,5,7,8). The needle-like CaP crystals are stacked parallel to each other, creating a hydrophilic effect beneficial for the adsorption of growth factors and adhesion of bone cells(6).

UniglideUnlike conventional '˜line of sight' plasma spraying processes, electrolysis allows for complete and uniform coverage of all exposed implant surfaces, whilst maintaining the surface roughness of the underlying titanium porous coated implant(4).

A biphasic CaP coating, the soluble brushite phase in Biomimetic Cementless Technology gets resorbed rapidly promoting short-term bone synthesis. In vivo studies have shown that, unlike conventional, highly crystalline HA coatings, the co-ordinated bioactivity exhibited by Biomimetic Cementless Technology provides excellent short and long-term osseointegration(1,2,3,5,7,9).

Clinical trials have demonstrated that Biomimetic Cementless Technology is fully resorbable, disappearing into the joint space within 8-12 weeks of implantation, allowing for exposure of the porous structure to rapidly deposited bone tissue(3,10).  This provides instant mechanical interlock between the developing bone and underlying implant.



1. Wood PLR, Deakin S. Total ankle replacement. The results in 200 ankles. J Bone Joint Surg (Br) 2003; 85-B:3:334.

2. Saxler G, Temmen D, Bontemps G. Medium-term results of AMC-unicompartmental knee arthroplasty. The Knee 2004; 11:39-355.

3. Schwarz ML, Kowarsch M, Rose SB, Jani L. Histomorphometrical and mechanical evaluation of various surfaces on titanium test bodies placed into femora of the Göttinger minipig. Can a resorbable CaP coating increase osteointegration? 49th Annual Meeting of the Orthopaedic Research Society 2003; Poster.

4. DOT GmbH internal test report. Data on file Corin Group 2009.

5. Becker P, Nebe B, Luthen F, Rychle J, Neumann HG. Cellular investigations on electrochemically deposited CaP-composite. 18th European Conference on Biomaterials 2003. Abstract.

6. Szmukler-Moncler S, Becker P, Kunemann P, Nardin M. Capillarity measurement of various FBR/BONIT-coated titanium surfaces. European Association for Osseointegration 2003; Poster.

7. Zeggel P. Bioactive Calcium phosphate coatings for dental implants. A summarising characterisation of BONIT-FBR. International Magazine of Oral Implantology 1/2000; 51-57.

8. Zeggel P, Becker P. BONIT®. A biomimetic calcium phosphate coating connects bone and implant surfaces. BONEZone Summer 2003.

9. Massei G, Trisi P, Malchiodi L, Szmukler-Moncler S. Immediately loaded FBR-coated PITT-EASY BIO-OSS Implants. A histologic evaluation in 3 patients after 8-12 weeks of function. European Association for Osseointegration 2001; Poster.

10. Becker P, Zeggel P, Luthen F, Nebe B, Rychly J, Neumann HG. Resorbable calcium phosphate composite coatings. Key Engineering Materials 2002; 218-220:653-656.


Important: Not all products are available or cleared for distribution in all international markets. For more details, please contact your local subsidiary or distributor by visiting the Corin worldwide section.

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